AUFMC was established by a group of civic-minded individuals who responded to the public need for a modern and efficient medical facility. It was inaugurated on February 23, 1990 with President Corazon C. Aquino as Principal Sponsor, President Diosdado P. Macapagal as Chairman of the Board, and Dr. Emmanuel Y. Angeles as President and Chief Executive Officer.
AUFMC formally opened on May 25, 1990. The construction of the first building was made possible through the Hospital Loan Program of the Philippine Social Security System. The initial acquisition of hospital equipment was financed by the Development Bank of the Philippines and additional equipment, furniture and supplies were donated by hospitals in California, USA.
AUFMC also won a bid to acquire the entire St. Anthony’s Family Medical Center in Milwaukee, Wisconsin, through the intervention of Cardinal Jaime Sin, Archbishop of Manila and the Archbishop of Milwaukee.